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Titanium 2006 Antivirus & Antispyware
Speaking of resources I installed it on an old 200Mhz machine with 128Mh or RAM running Windows 98 and it worked. Granted that machine can barely run Windows 98 but it handled Titanium Antivirus and Antispyware with no problem.
Buying it gives you one year of updates. Yeah, I know, the antivirus update cycle is a bear of a treadmill but this one is worth it.